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I'm sure everyone has a question about the world of One Piece that has yet to be answered. We all want our questions to be answered in the New World. Well I have a question that has not been answered(as far as my knowledge).

What makes human into big human like Whitebeard or the Blackbeard Pirates? Is there some kind of special training one must go through? Is it hereditary?

What unanswered questions that you have that you hope will be answered in the New World?