I got the idea from RandomKing57's blog Randomized Devil Fruit Game in which I was unfortunate enough to get the Moku Moku no Mi. As someone who does not smoke and is in fact anti-smoking this is probably the most unfortunate DF power for me. So, I started wondering if there are other such unfortunate combinations.
Maybe someone who's allergic to cats who eats the Neko Neko no Mi? Or a neat freak with the Numa Numa no Mi. Or a Vegan with the power of the Niku Niku no Mi!
What do you think is a particularly unfortunate combination of character and DF?