SIQ is a drug developed by Indigo the doctor of the Golden Lion Pirates, to make animals "evolve" and develop special abilities (i.e. giant size, mutation). Shiki used this to build his army of mutated animals for twenty years, in the hopes to overthrow the world. The Straw Hat Pirates eventually destroyed the entire stock when they bombed Indigo's lab.
This substance is derived from a natural substance called IQ, only known in Merveille. The IQ originally makes the animals evolve adapting to their habitat. As Indigo developed the SIQ, the more he injects this substance into animals, the more developed their battle instincts become, and as a result, their nature becomes more and more violent.
- ↑ One Piece Manga and Anime - Vol. 0 Chapter 0 and Episode 0, Indigo builds an army of mutant animals via SIQ for twenty years.
- ↑ One Piece Anime - Movie 10, Indigo explains about the SIQ.