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The Straw Hat Pirates finally enter the New World, but soon receive a distress call from Punk Hazard island, home to a former laboratory of Dr. Vegapunk. They become entangled in the illegal experiments of Caesar Clown, and form an alliance with Trafalgar Law in preparation for dethroning Kaido of the Yonko. They challenge Donquixote Doflamingo and uncover a decade-long conspiracy on Dressrosa island. Their resulting actions against the Shichibukai send a massive shockwave throughout the world and result in the birth of the Straw Hat Grand Fleet.
- Punk Hazard Arc: (Manga: 2012-2013) (Anime: 2013)
- Dressrosa Arc: (Manga: 2013-2015) (Anime: 2014-2016)
- This is the largest saga in both the manga and anime, surpassing the Water 7 Saga's 139 chapters and the Summit War Saga's 122 episodes.