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The Straw Hat Pirates finally enter the New World, but soon after receive a distress call from an island called Punk Hazard, home to a former laboratory of Dr. Vegapunk, where they become entangled in the illegal experiments of Caesar Clown. In the midst of this, they form an alliance with Trafalgar Law, in preparation for dethroning Kaido of the Yonko. In order to do so, they challenge Donquixote Doflamingo and uncover a decade-long conspiracy on the island of Dressrosa. Their resulting actions against the Shichibukai send a massive shockwave throughout the world and result in the birth of the Straw Hat Grand Fleet.
- Punk Hazard Arc: (Manga: 2012-2013) (Anime: 2013)
- Dressrosa Arc: (Manga: 2013-2015) (Anime: 2014-2016)
- This is the largest saga in both the manga and anime, surpassing the Water 7 Saga's 139 chapters and the Summit War Saga's 122 episodes.